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Bcor loss promotes Richter transformation of chronic lymphocytic leukemia associated with Notch1 activation in mice

Richter’s transformation (RT) is an aggressive lymphoma occurring upon progression from chronic lymphocytic leukemia (CLL). Despite advances in deciphering the RT genetic architecture, the mechanisms driving this disease remain unknown. BCOR disruptive mutations were found in CLL and frequently associated with NOTCH1 aberrations, a common feature in CLL and RT. We engineered mice to knock-out Bcor in B and CLL cells of Eμ-TCL1 mice. Bcor loss resulted in alterations of the B cell compartment ...

Damage-sensitive electrically conductive mortars: a novel laboratory characterization method and initial numerical simulations

In this paper, the authors propose innovative damage-sensitive electrically conductive mortar layers to monitor crack formation and propagation in masonry structures. The inclusion of a sufficient amount of suitable electrically conductive fillers in cement mortar formulations is shown to promote the development of an improved electromechanical response of the material, which can be exploited for Structural Health Monitoring (SHM) purposes. Specifically, consistent changes in the electrical c...

Selenium-biofortified pollen from Olea europaea L. retains germination capacity under heat stress and oxidative imbalance

Hydrogen peroxide-induced oxidative stress disrupts cytosolic Ca²⁺ homeostasis, a critical indicator of pollen fertility. Thus, measuring Ca²⁺ levels provides valuable insights into the role of antioxidants in protecting plant reproductive processes. Given the established link between high temperatures and oxidative stress, this study evaluates the response of selenium (Se)-biofortified pollen from Olea europaea L. (Leccino cultivar) to combined thermal and oxidative challenges. Pollen from u...

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Prodotti recenti

Bcor loss promotes Richter transformation of chronic lymphocytic leukemia associated with Notch1 activation in mice

Damage-sensitive electrically conductive mortars: a novel laboratory characterization method and initial numerical simulations

Selenium-biofortified pollen from Olea europaea L. retains germination capacity under heat stress and oxidative imbalance

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